A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

Andreas Diepold; Erdinc Sezgin; Miles Huseyin; Thomas Mortimer; Christian Eggeling; Judith P. Armitage

doi:10.1038/ncomms15940

Nature Communications (Jun 2017)

A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

Andreas Diepold,
Erdinc Sezgin,
Miles Huseyin,
Thomas Mortimer,
Christian Eggeling,
Judith P. Armitage

Affiliations

Andreas Diepold: Department of Biochemistry, University of Oxford
Erdinc Sezgin: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
Miles Huseyin: Department of Biochemistry, University of Oxford
Thomas Mortimer: Department of Biochemistry, University of Oxford
Christian Eggeling: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
Judith P. Armitage: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/ncomms15940
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Bacterial type III secretion systems (T3SS) play important roles in pathogenesis. Here, Diepoldet al. show the dynamic nature of complexes formed of essential T3SS components in live bacteria, and that extracellular calcium concentrations influence these cytosolic complexes likely via SctK/YscK.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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