COPD (Dec 2022)
Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China
- Dingyi Wang,
- Guohui Fan,
- Sinan Wu,
- Ting Yang,
- Jianying Xu,
- Lan Yang,
- Jianping Zhao,
- Xiangyan Zhang,
- Chunxue Bai,
- Jian Kang,
- Pixin Ran,
- Huahao Shen,
- Fuqiang Wen,
- Kewu Huang,
- Yahong Chen,
- Tieying Sun,
- Guangliang Shan,
- Yingxiang Lin,
- Guodong Xu,
- Ruiying Wang,
- Zhihong Shi,
- Yongjian Xu,
- Xianwei Ye,
- Yuanlin Song,
- Qiuyue Wang,
- Yumin Zhou,
- Wen Li,
- Liren Ding,
- Chun Wan,
- Wanzhen Yao,
- Yanfei Guo,
- Fei Xiao,
- Yong Lu,
- Xiaoxia Peng,
- Biao Zhang,
- Dan Xiao,
- Zuomin Wang,
- Xiaoning Bu,
- Hong Zhang,
- Xiaolei Zhang,
- Li An,
- Shu Zhang,
- Jianguo Zhu,
- Zhixin Cao,
- Qingyuan Zhan,
- Yuanhua Yang,
- Lirong Liang,
- Huaping Dai,
- Bin Cao,
- Jiang He,
- Chen Wang,
- for the China Pulmonary Health (CPH) Study Group
Affiliations
- Dingyi Wang
- China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences
- Guohui Fan
- China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences
- Sinan Wu
- Center of Respiratory Medicine, China-Japan Friendship Hospital
- Ting Yang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Jianying Xu
- Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital
- Lan Yang
- Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University
- Jianping Zhao
- Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiangyan Zhang
- Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s Hospital
- Chunxue Bai
- Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University
- Jian Kang
- Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University
- Pixin Ran
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University
- Huahao Shen
- Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine
- Fuqiang Wen
- State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University
- Kewu Huang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Yahong Chen
- Department of Respiratory and Critical Care Medicine, Peking University Third Hospital
- Tieying Sun
- Department of Respiratory and Critical Care Medicine, Beijing Hospital
- Guangliang Shan
- Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences
- Yingxiang Lin
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Guodong Xu
- China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences
- Ruiying Wang
- Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital
- Zhihong Shi
- Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi’an Jiaotong University
- Yongjian Xu
- Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xianwei Ye
- Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People’s Hospital
- Yuanlin Song
- Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University
- Qiuyue Wang
- Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University
- Yumin Zhou
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University
- Wen Li
- Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine
- Liren Ding
- Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine
- Chun Wan
- State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University
- Wanzhen Yao
- Department of Respiratory and Critical Care Medicine, Peking University Third Hospital
- Yanfei Guo
- Department of Respiratory and Critical Care Medicine, Beijing Hospital
- Fei Xiao
- National Center of Gerontology, Beijing Hospital
- Yong Lu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Xiaoxia Peng
- Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
- Biao Zhang
- Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences
- Dan Xiao
- Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Zuomin Wang
- Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University
- Xiaoning Bu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Hong Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Xiaolei Zhang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Li An
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Shu Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Jianguo Zhu
- National Center of Gerontology, Beijing Hospital
- Zhixin Cao
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Qingyuan Zhan
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Yuanhua Yang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University
- Lirong Liang
- Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University
- Huaping Dai
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Bin Cao
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Chen Wang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital
- for the China Pulmonary Health (CPH) Study Group
- DOI
- https://doi.org/10.1080/15412555.2022.2042504
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 118 – 124
Abstract
Objective We aimed to establish an easy-to-use screening questionnaire with risk factors and suspected symptoms of COPD for primary health care settings. Methods Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between 2012 and 2015, participants ≥40 years who completed the questionnaire and spirometry tests were recruited and randomly divided into development set and validation set by the ratio of 2:1. Parameters including sex, age, BMI, residence, education, smoking status, smoking pack-years, biomass exposure, parental history of respiratory diseases and daily respiratory symptoms were initially selected for the development of scoring system. Receiver operating characteristic (ROC) curve, area under curve (AUC), positive and negative predictive values were calculated in development set and validation set. Results After random split by 2:1 ratio, 22443 individuals were assigned to development set and 11221 to validation set. Ten variables were significantly associated with COPD independently in development set after a stepwise selection by multivariable logistic model and used to develop scoring system. The scoring system yielded good discrimination, as measured by AUC of 0.7737, and in the validation set, the AUC was 0.7711. When applying a cutoff point of ≥16, the sensitivity in development set was 0.69 (0.67 − 0.71); specificity 0.72 (0.71 − 0.73), PPV 0.25 (0.24 − 0.26) and NPV 0.94 (0.94 − 0.95). Conclusion We developed and validated a comprehensive screening questionnaire, COPD-CPHS, with good discrimination. The score system still needs to be validated by large cohort in the future. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2042504 .
Keywords
