Communications Biology (Feb 2023)

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

  • Jacinda Chen,
  • Amaury Cazenave-Gassiot,
  • Yimeng Xu,
  • Paola Piroli,
  • Robert Hwang,
  • Laura DeFreitas,
  • Robin Barry Chan,
  • Gilbert Di Paolo,
  • Renu Nandakumar,
  • Markus R. Wenk,
  • Catherine Marquer

DOI
https://doi.org/10.1038/s42003-023-04573-z
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 11

Abstract

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Lysosomal phospholipase A2 (LPLA2) is the PG to LPG converting enzyme in the BMP biosynthetic pathway, and changes in LPLA2 levels in cells affect cholesterol levels and late endosome/lysosome morphology.