Molecular Insights on Binding Interactions of Cyclooxygenase and Lipoxygenase Activities on Malondialdehyde in Naphthalene-Exposed Wistar Rats

Abstract

Naphthalene (NA), a polycyclic aromatic hydrocarbon, is an environmental pollutant from different sources exhibiting toxicities via free radical generation. However, NA has been used in the industry as surfactants, solvents, resins, and in medicine – as an anti-viral, anti-bacterial, and antiinflammatory drug. Malondialdehyde (MDA), a by-product in lipid peroxidation and prostaglandin synthesis, is a biomarker in lipid peroxidation evaluation and cyclooxygenase (COX) and lipoxygenase (LOX) activities assessment via inhibition.

Keywords

• naphthalene
• malondialdehyde
• cyclooxygenase
• lipoxygenase
• 1-nitronaphthalene