Neural Regeneration Research (Jan 2024)

Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury: a randomized controlled study

  • Hui Zhu,
  • James D Guest,
  • Sarah Dunlop,
  • Jia-Xin Xie,
  • Sujuan Gao,
  • Zhuojing Luo,
  • Joe E Springer,
  • Wutian Wu,
  • Wise Young,
  • Wai Sang Poon,
  • Song Liu,
  • Hongkun Gao,
  • Tao Yu,
  • Dianchun Wang,
  • Libing Zhou,
  • Shengping Wu,
  • Lei Zhong,
  • Fang Niu,
  • Xiaomei Wang,
  • Yansheng Liu,
  • Kwok-Fai So,
  • Xiao-Ming Xu

DOI
https://doi.org/10.4103/NRR.NRR-D-23-01198
Journal volume & issue
Vol. 19, no. 12
pp. 2773 – 2784

Abstract

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For patients with chronic spinal cord injury, the conventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection, pressure sores, osteoporosis, and deep vein thrombosis. Surgery is rarely performed on spinal cord injury in the chronic phase, and few treatments have been proven effective in chronic spinal cord injury patients. Development of effective therapies for chronic spinal cord injury patients is needed. We conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal cord injury to compare intensive rehabilitation (weight-bearing walking training) alone with surgical intervention plus intensive rehabilitation. This clinical trial was registered at ClinicalTrials.gov (NCT02663310). The goal of surgical intervention was spinal cord detethering, restoration of cerebrospinal fluid flow, and elimination of residual spinal cord compression. We found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement, reduced spasticity, and more rapid bowel and bladder functional recovery than weight-bearing walking training alone. Overall, the surgical procedures and intensive rehabilitation were safe. American Spinal Injury Association Impairment Scale improvement was more common in T7–T11 injuries than in T2–T6 injuries. Surgery combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

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