PIP2 determines length and stability of primary cilia by balancing membrane turnovers

Simon Stilling; Theodoros Kalliakoudas; Hannah Benninghoven-Frey; Takanari Inoue; Björn H Falkenburger

doi:10.1038/s42003-022-03028-1

Communications Biology (Jan 2022)

PIP2 determines length and stability of primary cilia by balancing membrane turnovers

Simon Stilling,
Theodoros Kalliakoudas,
Hannah Benninghoven-Frey,
Takanari Inoue,
Björn H Falkenburger

Affiliations

Simon Stilling: Department of Neurology, RWTH Aachen University
Theodoros Kalliakoudas: Department of Neurology, TU Dresden
Hannah Benninghoven-Frey: Department of Neurology, RWTH Aachen University
Takanari Inoue: Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University
Björn H Falkenburger: Department of Neurology, RWTH Aachen University

DOI: https://doi.org/10.1038/s42003-022-03028-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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By using methods to synthesise or degrade PIP2 selectively in the ciliary membrane, Stilling et al. find that PIP2 levels determine the length of primary cilia. They show that various pathways converge on PIP2 which induces ciliary fission in a manner dependent on actin, AurkA and HDAC6.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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