Nature Communications (Sep 2016)
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
- Khanh V. Doan,
- Ann W. Kinyua,
- Dong Joo Yang,
- Chang Mann Ko,
- Sang Hyun Moh,
- Ko Eun Shong,
- Hail Kim,
- Sang-Kyu Park,
- Dong-Hoon Kim,
- Inki Kim,
- Ji-Hye Paik,
- Ronald A. DePinho,
- Seul Gi Yoon,
- Il Yong Kim,
- Je Kyung Seong,
- Yun-Hee Choi,
- Ki Woo Kim
Affiliations
- Khanh V. Doan
- Department of Pharmacology, Wonju College of Medicine, Yonsei University
- Ann W. Kinyua
- Department of Pharmacology, Wonju College of Medicine, Yonsei University
- Dong Joo Yang
- Department of Pharmacology, Wonju College of Medicine, Yonsei University
- Chang Mann Ko
- Department of Pharmacology, Wonju College of Medicine, Yonsei University
- Sang Hyun Moh
- Anti-aging Research Institute of BIO-FD&C Co. Ltd.
- Ko Eun Shong
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Hail Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
- Sang-Kyu Park
- Department of Biochemistry, College of Medicine, Catholic Kwandong University
- Dong-Hoon Kim
- Department of Pharmacology, Korea University College of Medicine
- Inki Kim
- Asan Institute for Life Sciences, Asan Medical Center
- Ji-Hye Paik
- Department of Pathology and Laboratory Medicine, Weill Cornell Medical College
- Ronald A. DePinho
- Department of Cancer Biology, University of Texas MD Anderson Cancer Center
- Seul Gi Yoon
- Laboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary Science
- Il Yong Kim
- Laboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary Science
- Je Kyung Seong
- Laboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary Science
- Yun-Hee Choi
- Anti-aging Research Institute of BIO-FD&C Co. Ltd.
- Ki Woo Kim
- Department of Pharmacology, Wonju College of Medicine, Yonsei University
- DOI
- https://doi.org/10.1038/ncomms12733
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Dopaminergic neurons are important for regulating energy homeostasis. Here, the authors show the transcription factor FoxO1 negatively regulates tyrosine hydroxylase expression in midbrain dopaminergic neurons, and plays an important role in regulation of glucose homeostasis, energy expenditure, and resistance to diet-induced obesity.
