Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency

Abstract

We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–interferon-γ autoantibodies, in addition to HIV infection, can lead to disseminated nontuberculous mycobacterial infection.

Keywords

• Mycobacterium genavense
• adult-onset immunodeficiency
• bacteria
• Tuberculosis and other mycobacteria
• Japan
• nontuberculous mycobacteria