USE OF DNA ISOLATED FROM BONE MARROW SAMPLES IN PARAFFIN BLOCKS FROM PATIENTS WITH MPN TO ANALYZE SOMATIC MUTATIONS

Abstract

Myeloproliferative neoplasms (MPN) are a clonal disease characterized by impaired proliferation of myelopoietic cell lines. WHO recommends molecular genetic studies to confirm the diagnosis and determine the phenotypic form. It is assumed that the study of DNA isolated from bone marrow in paraffin blocks from triple-negative patients with MPN will reveal somatic mutations (in JAK2, CALR, MPL genes) associated with MPNThis study shows that bone marrow DNA in paraffin blocks from patients with MPN is suitable for genetic studies.

Keywords

• calr
• хронические миелопролиферативные неоплазии