Nature Communications (Feb 2017)
Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells
- Pietro Giuseppe Mazzara,
- Luca Massimino,
- Marta Pellegatta,
- Giulia Ronchi,
- Alessandra Ricca,
- Angelo Iannielli,
- Serena Gea Giannelli,
- Marco Cursi,
- Cinzia Cancellieri,
- Alessandro Sessa,
- Ubaldo Del Carro,
- Angelo Quattrini,
- Stefano Geuna,
- Angela Gritti,
- Carla Taveggia,
- Vania Broccoli
Affiliations
- Pietro Giuseppe Mazzara
- Division of Neuroscience, San Raffaele Scientific Institute
- Luca Massimino
- Division of Neuroscience, San Raffaele Scientific Institute
- Marta Pellegatta
- Division of Neuroscience, Axo-glia Interactions Unit-INSPE, San Raffaele Institute
- Giulia Ronchi
- Department of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Ospedale San Luigi
- Alessandra Ricca
- Division of Regenerative Medicine, SR-Tiget, Stem Cells and Gene Therapy, San Raffaele Scientific Institute
- Angelo Iannielli
- Division of Neuroscience, San Raffaele Scientific Institute
- Serena Gea Giannelli
- Division of Neuroscience, San Raffaele Scientific Institute
- Marco Cursi
- Department of Neurology, Neurophysiology and Neurorehabilitation Unit-INSPE, San Raffaele Scientific Institute
- Cinzia Cancellieri
- Division of Neuroscience, San Raffaele Scientific Institute
- Alessandro Sessa
- Division of Neuroscience, San Raffaele Scientific Institute
- Ubaldo Del Carro
- Department of Neurology, Neurophysiology and Neurorehabilitation Unit-INSPE, San Raffaele Scientific Institute
- Angelo Quattrini
- Department of Neurology, Neuropathology Unit-INSPE, San Raffaele Scientific Institute
- Stefano Geuna
- Department of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Ospedale San Luigi
- Angela Gritti
- Division of Regenerative Medicine, SR-Tiget, Stem Cells and Gene Therapy, San Raffaele Scientific Institute
- Carla Taveggia
- Division of Neuroscience, Axo-glia Interactions Unit-INSPE, San Raffaele Institute
- Vania Broccoli
- Division of Neuroscience, San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/ncomms14088
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Schwann cells (SCs) myelinate peripheral nerve axons and offer opportunities for the treatment of injuries and demyelinating diseases but reliable and renewable sources of these cells are hard to come by. Here the authors reprogram rat, mouse and human fibroblasts into Schwann cells using two transcription factors.
