EFFICACY OFINFLIXIMABIN THE TREATMENTOF CROHN’S DISEASEIN CHILDREN

Abstract

This paper shows the research results of the biological therapy with chimeric monoclonal antibody to tumor necrosis factor (TNF) (infliximab). 33 children aged 6 to 18 years with various forms of Crohn’s disease were enrolled in the study. Therapy duration ranged from 3 months to 1 year or more. After the induction course of therapy efficacy was 94%, clinical remission was achieved in 70% of patients, after 1 year of therapy efficacy of therapy was reduced to 84%, clinical remission was observed in 70% of children. Endoscopic remission rate after induction was observed in 24% of children, and in 29% after 54 weeks of therapy. After one year of treatment in 9 out of 11 children glucocorticoid therapy was completely stopped. Adverse events after infliximab administration were observed in 9% of children. One child was withdrawn from the study due to infliximab intolerance.

Keywords

• children
• crohn’s disease
• treatment with infliximab