CHLORIDE-2-[(1Z)-1-(3,5-DIPHENYL-1,3,4-THYADIAZOLE-2(3H)-ILIDEN)METHYL]-3,5-DIPHENYL-1,3,4-THYADIAZOLE-3 AS A PROMISING COMPOUND FOR THE DEVELOPMENT OF NEW DRUGS

Abstract

The method of obtaining new heterocyclic compound - chloride 2-[(1Z)-1-(3,5-diphenyl-1,3,4-thiadiazol-2(3H)-ilidene)methyl]-3,5-diphenyl-1,3,4-thiadiazol-3-Ia was developed. Its structure was proved by physicochemical methods of identification of organic compounds: 1Н- and 13С-NMR-, IR-spectrometry, mass spectrometry. Antifungal activity was defined against С. albicans, T. rubrum, T. mentagrophytes, F. proliferatum, S. brevicaulis . It was shown that this compound has potent antifungal activity and can potentially be used in medicine as antimicrobial with fungicidal action.

Keywords

• 1,3,4-thiadiazole
• antifungal activity
• the minimal inhibitory concentration