Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Abstract

Madeleine Petersson-Sjögren,1,2 Jonas Jakobsson,3 H Laura Aaltonen,4,5 Hanna Nicklasson,6,7 Jenny Rissler,1,2,8 Gunnar Engström,9 Per Wollmer,6 Jakob Löndahl1,2 1Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Lund University, Lund, Sweden; 2NanoLund, Lund University, Lund, Sweden; 3Division of Nuclear Physics, Department of Physics, Lund University, Lund, Sweden; 4Department of Translational Medicine, Medical Imaging and Physiology, Lund University, Malmö, Sweden; 5Department of Radiology, University of Washington, Seattle, WA, USA; 6Department of Translational Medicine, Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Malmö, Sweden; 7MVIC Medicon Valley Inhalation Consortium AB, Lund, Sweden; 8Division of Bioeconomy and Health, RISE Research Institutes of Sweden, Borås, Sweden; 9Department of Clinical Sciences, Lund University, Malmö, SwedenCorrespondence: Jakob Löndahl, Division of Ergonomics and Aerosol Technology, Lund University, Box 118, Lund, SE-221 00, Sweden, Email [email protected]: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context.Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis.Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent.Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.Keywords: aerosol nanoparticles, respiratory diagnostics with nanoparticles, distal airspaces, COPD diagnostics, airspace dimension assessment with nanoparticles

Keywords

• aerosol nanoparticles
• respiratory diagnostics with nanoparticles
• distal airspaces
• copd diagnostics
• airspace dimension assessment with nanoparticles