Effect of Sumanas, a polyherbal formulation, on learning and memory in animal models of Alzheimer's disease

Abstract

Objective: The current study was designed to scientifically validate the effect of Sumanas (SMS), a polyherbal formulation, against the Colchicine-induced animal model of Alzheimer's disease. Methods: The memory enhancing the activity of SMS was demonstrated by colchicine induced model. The anti-Alzheimer activity was studied by evaluating serum levels of GSH, LPO, CAT, AChE contents. Results and Discussion: Colchicine produced a significant alteration in serum enzymes namely, LPO, GSH, CAT, AChE levels but this was reversed by oral administration of Sumanas (25, 50, 100 mg/Kg) in a dose-dependent manner. Conclusion: The results of the current study establish, Sumanas can be utilized as appropriate herbal medicine to treat Alzheimer's disease models since it has improved the cognitive impairment through memory enhancing property.

Keywords

• alzheimer's disease
• sumanas
• colchicine
• cognitive impairment