Frontiers in Bioengineering and Biotechnology (May 2024)
Small diameter vascular grafts: progress on electrospinning matrix/stem cell blending approach
- Nuoxin Wang,
- Nuoxin Wang,
- Nuoxin Wang,
- Nuoxin Wang,
- Jiajing Chen,
- Jiajing Chen,
- Jiajing Chen,
- Jiajing Chen,
- Qingqing Hu,
- Qingqing Hu,
- Qingqing Hu,
- Qingqing Hu,
- Yunfeng He,
- Yunfeng He,
- Yunfeng He,
- Yunfeng He,
- Pu Shen,
- Pu Shen,
- Pu Shen,
- Pu Shen,
- Dingkun Yang,
- Dingkun Yang,
- Dingkun Yang,
- Dingkun Yang,
- Haoyuan Wang,
- Haoyuan Wang,
- Haoyuan Wang,
- Dong Weng,
- Dong Weng,
- Dong Weng,
- Dong Weng,
- Zhixu He,
- Zhixu He,
- Zhixu He,
- Zhixu He,
- Zhixu He
Affiliations
- Nuoxin Wang
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Nuoxin Wang
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Nuoxin Wang
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Nuoxin Wang
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Jiajing Chen
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Jiajing Chen
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Jiajing Chen
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Jiajing Chen
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Qingqing Hu
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Qingqing Hu
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Qingqing Hu
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Qingqing Hu
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Yunfeng He
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Yunfeng He
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Yunfeng He
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Yunfeng He
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Pu Shen
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Pu Shen
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Pu Shen
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Pu Shen
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Dingkun Yang
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Dingkun Yang
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Dingkun Yang
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Dingkun Yang
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Haoyuan Wang
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Haoyuan Wang
- Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Haoyuan Wang
- The Second Clinical Institute, Zunyi Medical University, Zunyi, China
- Dong Weng
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Dong Weng
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Dong Weng
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Dong Weng
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Zhixu He
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Zhixu He
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Zhixu He
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
- Zhixu He
- The First Clinical Institute, Zunyi Medical University, Zunyi, China
- Zhixu He
- Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- DOI
- https://doi.org/10.3389/fbioe.2024.1385032
- Journal volume & issue
-
Vol. 12
Abstract
The exploration of the next-generation small diameter vascular grafts (SDVGs) will never stop until they possess high biocompatibility and patency comparable to autologous native blood vessels. Integrating biocompatible electrospinning (ES) matrices with highly bioactive stem cells (SCs) provides a rational and promising solution. ES is a simple, fast, flexible and universal technology to prepare extracellular matrix-like fibrous scaffolds in large scale, while SCs are valuable, multifunctional and favorable seed cells with special characteristics for the emerging field of cell therapy and regenerative medicine. Both ES matrices and SCs are advanced resources with medical application prospects, and the combination may share their advantages to drive the overcoming of the long-lasting hurdles in SDVG field. In this review, the advances on SDVGs based on ES matrices and SCs (including pluripotent SCs, multipotent SCs, and unipotent SCs) are sorted out, and current challenges and future prospects are discussed.
Keywords
