Lead poisoning and its effects on bone density

Abstract

Abstract Lead poisoning is a significant health concern, impacting multiple organs in the body, including the musculoskeletal system. While some studies suggest a link between lead exposure and reduced Bone Mineral Density (BMD), others report no significant relationship. This study aims to address this research gap by comparing the prevalence of osteoporosis and BMD in patients with lead poisoning to that of healthy individuals. In this study, 35 lead poisoning patients admitted to the poisoning departments of Valiasr Hospital in Birjand and Imam Reza Hospital in Mashhad were compared with 35 age- and gender-matched healthy controls. The healthy group had Blood Lead concentrations (BLC), 0.05). The mean Z and T scores of femur in both groups showed no significant difference (P > 0.05). In contrast, the mean T and Z scores of L1, L2, L3, and L4 lumbar bones in the lead poisoning group were significantly lower than those in the healthy group (P < 0.05). The results of this study suggest that the prevalence of osteoporosis in people with lead poisoning is not different from that in healthy individuals. Nonetheless, bone density indices of lumbar vertebrae were affected in lead-poisoned individuals.

Keywords

• Osteoporosis
• Lead poisoning
• Bone density
• Lead