Reduction of Myopic Progression Using a Multifocal Soft Contact Lens: A Retrospective Cohort Study

Abstract

Jeffrey Cooper,1,2 Brett O’Connor,3 Thomas Aller,4,5 Sally M Dillehay,6 Katherine Weibel,7 Douglas Benoit8 1Cooper Eye Care, New York, NY, USA; 2State University of New York College of Optometry, New York, NY, USA; 3MyEyeDr – Mandarin, Jacksonville, FL, USA; 4Dr. Thomas Aller, Optometrist, Inc., San Bruno, CA, USA; 5University of California, Berkeley School of Optometry, Berkeley, CA, USA; 6ClintrialSolutions, LLC, Roswell, GA, USA; 7The Ohio State University College of Medicine, Department of Ophthalmology, Columbus, OH, USA; 8Visioneering Technologies, Inc., Alpharetta, GA, USACorrespondence: Douglas Benoit, Visioneering Technologies, Inc, Alpharetta, GA, 30009, USA, Email [email protected]: To evaluate myopia progression over an approximately 6-year follow-up period in children and young adults wearing a commercially available, daily disposable, soft multifocal contact lens with an extended depth of focus (center distance) design.Methods: This retrospective cohort analysis included data from 196 patients of mean (SD) age 12.3 (2.7) years (range, 5– 20 years), fit with the NaturalVue Multifocal (NVMF) contact lens at 15 practices in the United States over 6 years. All patients showed at least − 0.50D of myopic progression in at least one eye prior to wearing the lens. Data from the right eye were analyzed. One-way ANOVA with Tukeys post-hoc t-tests were used for statistical analysis, with a significance level set at P < 0.05.Results: After wearing these lenses for 6– 72 months, the average myopia progression slowed by approximately 0.84 D or 85% compared to baseline, which was statistically significant at all time points (P < 0.0001). Frequency distribution revealed that 91% of wearers showed a decrease in myopia progression compared to baseline, with 79% of wearers showing a ≥ 70% reduction in myopia progression. The average change in axial length in a subset of the population over 47 months of follow-up was approximately 0.10 mm/year. Compared with changes expected in an age- and ethnicity-matched myopic virtual control group obtained from published meta-analysis data, both myopic refractive error progression and axial elongation were significantly lower in NVMF wearers at 12, 24 and 36 months (P < 0.001). Analysis of the age- and ethnicity-matched virtual control group predicted that the Cumulative Absolute Reduction of axial Elongation (CARE) value over 3 years would be 0.45 mm.Conclusion: Wearers of the soft multifocal contact lens displayed significant reductions in myopia progression throughout a follow-up period of 6 years.Keywords: myopia, myopia progression control, soft multifocal contact lenses, peripheral hyperopia

Keywords

• myopia
• myopia progression control
• soft multifocal contact lenses
• peripheral hyperopia