Vaccines
(Mar 2021)
Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies
Pedro M. Folegatti,
Amy Flaxman,
Daniel Jenkin,
Rebecca Makinson,
Lucy Kingham-Page,
Duncan Bellamy,
Fernando Ramos Lopez,
Jonathan Sheridan,
Ian Poulton,
Jeremy Aboagye,
Nguyen Tran,
Celia Mitton,
Rachel Roberts,
Alison M. Lawrie,
Adrian V. S. Hill,
Katie J. Ewer,
Sarah Gilbert
Affiliations
Pedro M. Folegatti
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Amy Flaxman
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Daniel Jenkin
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Rebecca Makinson
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Lucy Kingham-Page
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Duncan Bellamy
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Fernando Ramos Lopez
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Jonathan Sheridan
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Ian Poulton
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Jeremy Aboagye
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Nguyen Tran
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Celia Mitton
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Rachel Roberts
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Alison M. Lawrie
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Adrian V. S. Hill
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Katie J. Ewer
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Sarah Gilbert
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
DOI
https://doi.org/10.3390/vaccines9030262
Journal volume & issue
Vol. 9,
no. 3
Abstract
Read online
Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.
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