Mediators of Inflammation (Jan 2004)

Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice

  • Kottarappat N. Dileepan,
  • Thomas P. Johnston,
  • Yuai Li,
  • Ossama Tawfik,
  • Daniel J. Stechschulte

DOI
https://doi.org/10.1080/09629350400008794
Journal volume & issue
Vol. 13, no. 5-6
pp. 335 – 341

Abstract

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STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sld mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sld mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sld genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sld mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sld mice.

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