Nature Communications (Dec 2019)
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
- Ekta Khattar,
- Kyaw Ze Ya Maung,
- Chen Li Chew,
- Arkasubhra Ghosh,
- Michelle Meng Huang Mok,
- Pei Lee,
- Jun Zhang,
- Wei Hong Jeff Chor,
- Gökhan Cildir,
- Chelsia Qiuxia Wang,
- Nur Khairiah Mohd-Ismail,
- Desmond Wai Loon Chin,
- Soo Chin Lee,
- Henry Yang,
- Yong-Jae Shin,
- Do-Hyun Nam,
- Liming Chen,
- Alan Prem Kumar,
- Lih Wen Deng,
- Masahito Ikawa,
- Jayantha Gunaratne,
- Motomi Osato,
- Vinay Tergaonkar
Affiliations
- Ekta Khattar
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Kyaw Ze Ya Maung
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Chen Li Chew
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Arkasubhra Ghosh
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Michelle Meng Huang Mok
- Cancer Science Institute of Singapore, National University of Singapore
- Pei Lee
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Jun Zhang
- Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University
- Wei Hong Jeff Chor
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Gökhan Cildir
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Chelsia Qiuxia Wang
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Nur Khairiah Mohd-Ismail
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Desmond Wai Loon Chin
- Cancer Science Institute of Singapore, National University of Singapore
- Soo Chin Lee
- Cancer Science Institute of Singapore, National University of Singapore
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Yong-Jae Shin
- Institute for Refractory Cancer Research, Samsung Medical Center
- Do-Hyun Nam
- Institute for Refractory Cancer Research, Samsung Medical Center
- Liming Chen
- Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University
- Alan Prem Kumar
- Cancer Science Institute of Singapore, National University of Singapore
- Lih Wen Deng
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Masahito Ikawa
- Research Institute for Microbial Diseases, Osaka University
- Jayantha Gunaratne
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- Motomi Osato
- Cancer Science Institute of Singapore, National University of Singapore
- Vinay Tergaonkar
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A-STAR)
- DOI
- https://doi.org/10.1038/s41467-019-13082-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumorigenesis, but enhanced sensitivity to genotoxic stress.
