Nature Communications (Jan 2020)

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

  • Natalia Moskal,
  • Victoria Riccio,
  • Mikhail Bashkurov,
  • Rediet Taddese,
  • Alessandro Datti,
  • Peter N. Lewis,
  • G. Angus McQuibban

DOI
https://doi.org/10.1038/s41467-019-13781-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.