Frontiers in Psychiatry (2019-11-01)

The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents

  • Letizia Squarcina,
  • Giuseppe Delvecchio,
  • Maria Nobile,
  • Maddalena Mauri,
  • Maddalena Mauri,
  • Domenico Madonna,
  • Domenico Madonna,
  • Carolina Bonivento,
  • Marco Garzitto,
  • Sara Piccin,
  • Massimo Molteni,
  • Barbara Tomasino,
  • Cinzia Bressi,
  • Franco Fabbro,
  • Jeffrey A. Stanley,
  • Paolo Brambilla

DOI
https://doi.org/10.3389/fpsyt.2019.00763
Journal volume & issue
Vol. 10

Abstract

Read online

Despite various advances in the study of the neurobiological underpinnings of personality traits, the specific neural correlates associated with character and temperament traits are not yet fully understood. Therefore, this study aims to fill this gap by exploring the biochemical basis of personality, which is explored with the temperament and character inventory (TCI), during brain development in a sample of adolescents. Twenty-six healthy adolescents (aged between 13 and 21 years; 17 males and 9 females) with behavioral and emotional problems underwent a TCI evaluation and a 3T single-voxel proton magnetic resonance spectroscopy (1H MRS) acquisition of the anterior cingulate cortex (ACC). Absolute metabolite levels were estimated using LCModel: significant correlations between metabolite levels and selective TCI scales were identified. Specifically, phosphocreatine plus creatine (PCr+Cre) significantly correlated with self-directedness, positively, and with a self-transcendence (ST), negatively, while glycerophosphocholine plus phosphocholine (GPC+PC) and myo-inositol negatively correlated with ST. To the best of our knowledge, this is the first study reporting associations of brain metabolites with personality traits in adolescents. Therefore, our results represent a step forward for personality neuroscience within the study of biochemical systems and brain structures.

Keywords