Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Andrew P. Sawaya; Rivka C. Stone; Stephen R. Brooks; Irena Pastar; Ivan Jozic; Kowser Hasneen; Katelyn O’Neill; Spencer Mehdizadeh; Cheyanne R. Head; Natasa Strbo; Maria I. Morasso; Marjana Tomic-Canic

doi:10.1038/s41467-020-18276-0

Nature Communications (Sep 2020)

Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Andrew P. Sawaya,
Rivka C. Stone,
Stephen R. Brooks,
Irena Pastar,
Ivan Jozic,
Kowser Hasneen,
Katelyn O’Neill,
Spencer Mehdizadeh,
Cheyanne R. Head,
Natasa Strbo,
Maria I. Morasso,
Marjana Tomic-Canic

Affiliations

Andrew P. Sawaya: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Rivka C. Stone: Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Stephen R. Brooks: Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Irena Pastar: Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Ivan Jozic: Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Kowser Hasneen: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Katelyn O’Neill: Department of Microbiology and Immunology, University of Miami Miller School of Medicine
Spencer Mehdizadeh: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Cheyanne R. Head: Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Natasa Strbo: Department of Microbiology and Immunology, University of Miami Miller School of Medicine
Maria I. Morasso: Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Marjana Tomic-Canic: Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1038/s41467-020-18276-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis and is dysregulated in patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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