Virology Journal (Jul 2021)
Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study
- Rui Huang,
- Li Zhu,
- Leyang Xue,
- Xuebing Yan,
- Jian Wang,
- Songping Huang,
- Biao Zhang,
- Tianmin Xu,
- Fang Ji,
- Chunyang Li,
- Fang Ming,
- Yun Zhao,
- Yang Li,
- Juan Cheng,
- Yinling Wang,
- Huaping Shao,
- Shuqin Hong,
- Kang Chen,
- Xiang-an Zhao,
- Dawen Sang,
- Lei Zou,
- Haiyan Zhao,
- Xinying Guan,
- Xiaobing Chen,
- Biyun Xu,
- Juan Xia,
- Yuxin Chen,
- Xiaomin Yan,
- Jie Wei,
- Jiacheng Liu,
- Longgen Liu,
- Chuanwu Zhu,
- Chao Wu
Affiliations
- Rui Huang
- Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Li Zhu
- Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University
- Leyang Xue
- Department of Critical Medicine, Huai’an No. 4 People’s Hospital
- Xuebing Yan
- Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University
- Jian Wang
- Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Songping Huang
- Department of Infectious Diseases, Nantong Third People’s Hospital, Nantong University
- Biao Zhang
- Department of Quality Control Office, Huai’an No. 4 People’s Hospital
- Tianmin Xu
- Department of Infectious Diseases, The Third People’s Hospital of Changzhou
- Fang Ji
- Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University
- Chunyang Li
- Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University
- Fang Ming
- Department of Infectious Diseases, Nantong Third People’s Hospital, Nantong University
- Yun Zhao
- Department of Infectious Diseases, The Third People’s Hospital of Yangzhou
- Yang Li
- Department of Infectious Diseases, Taizhou People’s Hospital
- Juan Cheng
- Department of Infectious Diseases, Yancheng Second People’s Hospital
- Yinling Wang
- Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University
- Huaping Shao
- Department of Infectious Diseases, The People’s Hospital of Suqian
- Shuqin Hong
- Nursing Department, Huai’an No. 4 People’s Hospital
- Kang Chen
- Department of Tuberculosis, The Third People’s Hospital of Changzhou
- Xiang-an Zhao
- Department of Gastroenterology, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University
- Dawen Sang
- Department of Infectious Diseases, Yancheng Second People’s Hospital
- Lei Zou
- Department of Infectious Diseases, Yancheng Second People’s Hospital
- Haiyan Zhao
- Department of Infectious Diseases, The People’s Hospital of Suqian
- Xinying Guan
- Department of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People’s Hospital of Lianyungang
- Xiaobing Chen
- Department of Emergency, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People’s Hospital of Lianyungang
- Biyun Xu
- Department of Biostatistics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Juan Xia
- Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Yuxin Chen
- Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Xiaomin Yan
- Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Jie Wei
- Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University
- Jiacheng Liu
- Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine
- Longgen Liu
- Department of Infectious Diseases, The Third People’s Hospital of Changzhou
- Chuanwu Zhu
- Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University
- Chao Wu
- Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- DOI
- https://doi.org/10.1186/s12985-021-01615-y
- Journal volume & issue
-
Vol. 18,
no. 1
pp. 1 – 8
Abstract
Abstract Background The clinical and virological course of patients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to describe the clinical and virological characteristics of COVID-19 patients from 10 designated hospitals in 10 cities of Jiangsu province, China. The factors associated with the clearance of SARS-CoV-2 were investigated. Methods A total of 328 hospitalized patients with COVID-19 were retrospectively recruited. The epidemiological, clinical, laboratory, radiology and treatment data were collected. The associated factors of SARS-CoV-2 clearance were analyzed. Results The median duration of hospitalization was 16.0 days (interquartile range [IQR] 13.0–21.0 days). On multivariate Cox regression analysis, age > 60 years (hazard ratio [HR] 0.643, 95% confidence interval [CI] 0.454–0.911, P = 0.013) was associated with the delayed SARS-CoV-2 clearance, while the atomized inhalation of interferon α-2b could improve the clearance of SARS-CoV-2 (HR, 1.357, 95% CI 1.050–1.755, P = 0.020). Twenty-six (7.9%) patients developed respiratory failure and 4 (1.2%) patients developed ARDS. Twenty (6.1%) patients were admitted to the ICU, while no patient was deceased. Conclusions Our study found that age > 60 years was associated with the delayed SARS-CoV-2 clearance, while treated with atomized inhalation of interferon α-2b could promote the clearance of SARS-CoV-2.
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