Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Harvind S. Chahal; Wenting Wu; Katherine J. Ransohoff; Lingyao Yang; Haley Hedlin; Manisha Desai; Yuan Lin; Hong-Ji Dai; Abrar A. Qureshi; Wen-Qing Li; Peter Kraft; David A. Hinds; Jean Y. Tang; Jiali Han; Kavita Y. Sarin

doi:10.1038/ncomms12510

Nature Communications (Aug 2016)

Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Harvind S. Chahal,
Wenting Wu,
Katherine J. Ransohoff,
Lingyao Yang,
Haley Hedlin,
Manisha Desai,
Yuan Lin,
Hong-Ji Dai,
Abrar A. Qureshi,
Wen-Qing Li,
Peter Kraft,
David A. Hinds,
Jean Y. Tang,
Jiali Han,
Kavita Y. Sarin

Affiliations

Harvind S. Chahal: Department of Dermatology, Stanford University School of Medicine
Wenting Wu: Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Katherine J. Ransohoff: Department of Dermatology, Stanford University School of Medicine
Lingyao Yang: Department of Medicine (Quantitative Sciences Unit), Stanford University School of Medicine
Haley Hedlin: Department of Medicine (Quantitative Sciences Unit), Stanford University School of Medicine
Manisha Desai: Department of Medicine (Quantitative Sciences Unit), Stanford University School of Medicine
Yuan Lin: Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Hong-Ji Dai: Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Abrar A. Qureshi: Department of Dermatology, Warren Alpert Medical School, Brown University
Wen-Qing Li: Department of Dermatology, Warren Alpert Medical School, Brown University
Peter Kraft: Department of Epidemiology, Harvard T.H. Chan School of Public Health
David A. Hinds: 23andMe Inc.
Jean Y. Tang: Department of Dermatology, Stanford University School of Medicine
Jiali Han: Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Kavita Y. Sarin: Department of Dermatology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/ncomms12510
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Basal cell carcinoma is a common skin lesion and the risk loci for this cancer are beginning to be understood. In this study, the authors conduct a two-stage genome-wide association study and confirm known risk loci and identify an additional 14 loci.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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