PLoS Biology (Nov 2021)

Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.

  • David Komla Kessie,
  • Thomas Rudel

DOI
https://doi.org/10.1371/journal.pbio.3001462
Journal volume & issue
Vol. 19, no. 11
p. e3001462

Abstract

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Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.