Molecules (Sep 2009)

Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis

  • Vincent Dumontet,
  • Bernard Kiremire,
  • Françoise Guéritte,
  • Marc Litaudon,
  • Sabrina Krief,
  • Marie-Thérèse Martin,
  • John Kasenene,
  • Min Xu

DOI
https://doi.org/10.3390/molecules14103844
Journal volume & issue
Vol. 14, no. 10
pp. 3844 – 3850

Abstract

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One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.

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