Frontiers in Human Neuroscience (Dec 2020)

Combining Gamma With Alpha and Beta Power Modulation for Enhanced Cortical Mapping in Patients With Focal Epilepsy

  • Mario E. Archila-Meléndez,
  • Mario E. Archila-Meléndez,
  • Mario E. Archila-Meléndez,
  • Mario E. Archila-Meléndez,
  • Giancarlo Valente,
  • Giancarlo Valente,
  • Giancarlo Valente,
  • Erik D. Gommer,
  • Erik D. Gommer,
  • João M. Correia,
  • João M. Correia,
  • João M. Correia,
  • Sanne ten Oever,
  • Sanne ten Oever,
  • Sanne ten Oever,
  • Judith C. Peters,
  • Judith C. Peters,
  • Judith C. Peters,
  • Joel Reithler,
  • Joel Reithler,
  • Joel Reithler,
  • Marc P. H. Hendriks,
  • Marc P. H. Hendriks,
  • Marc P. H. Hendriks,
  • William Cornejo Ochoa,
  • Olaf E. M. G. Schijns,
  • Olaf E. M. G. Schijns,
  • Olaf E. M. G. Schijns,
  • Jim T. A. Dings,
  • Jim T. A. Dings,
  • Danny M. W. Hilkman,
  • Danny M. W. Hilkman,
  • Rob P. W. Rouhl,
  • Rob P. W. Rouhl,
  • Rob P. W. Rouhl,
  • Rob P. W. Rouhl,
  • Bernadette M. Jansma,
  • Bernadette M. Jansma,
  • Bernadette M. Jansma,
  • Vivianne H. J. M. van Kranen-Mastenbroek,
  • Vivianne H. J. M. van Kranen-Mastenbroek,
  • Vivianne H. J. M. van Kranen-Mastenbroek,
  • Vivianne H. J. M. van Kranen-Mastenbroek,
  • Mark J. Roberts,
  • Mark J. Roberts

DOI
https://doi.org/10.3389/fnhum.2020.555054
Journal volume & issue
Vol. 14

Abstract

Read online

About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping (ESM) is the gold standard for the identification of “eloquent” areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity (55–200 Hz) recorded with extraoperative electrocorticography (ECoG) during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha (8–12 Hz) and beta (15–25 Hz) bands could further improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy (age: 35.9 ± 9.1 years, range: 22–48, 8 females, 9 right handed) participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model (GLM) approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic (ROC) curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient’s degree of attention to the stimulus. We show that diagnostic ability can be increased by 3–5% by combining gamma and alpha and by 7.5–11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy.

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