Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis

Yizhen Tang; Yizhen Tang; Simran Shah; Kin-Sang Cho; Xinghuai Sun; Dong Feng Chen

doi:10.3389/fnins.2022.835736

Frontiers in Neuroscience (May 2022)

Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis

Yizhen Tang,
Yizhen Tang,
Simran Shah,
Kin-Sang Cho,
Xinghuai Sun,
Dong Feng Chen

Affiliations

Yizhen Tang: Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Yizhen Tang: Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States
Simran Shah: Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States
Kin-Sang Cho: Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States
Xinghuai Sun: Department of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China
Dong Feng Chen: Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States

DOI: https://doi.org/10.3389/fnins.2022.835736
Journal volume & issue: Vol. 16

Abstract

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Glaucoma is a leading cause of blindness worldwide. It is suggested that primary open angle glaucoma (POAG), the most common form of glaucoma, may be associated with significant metabolic alternations, but the systemic literature review and meta-analysis in the area have been missing. Altered metabolomic profiles in the aqueous humor and plasma may serve as possible biomarkers for early detection or treatment targets. In this article, we performed a systematic meta-analysis of the current literature surrounding the metabolomics of patients with POAG and metabolites associated with the disease. Results suggest several metabolites found to be specifically altered in patients with POAG, suggesting broad generalizability and pathways for future research.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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