Nature Communications (Dec 2022)
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
- Michelle M. Kameda-Smith,
- Helen Zhu,
- En-Ching Luo,
- Yujin Suk,
- Agata Xella,
- Brian Yee,
- Chirayu Chokshi,
- Sansi Xing,
- Frederick Tan,
- Raymond G. Fox,
- Ashley A. Adile,
- David Bakhshinyan,
- Kevin Brown,
- William D. Gwynne,
- Minomi Subapanditha,
- Petar Miletic,
- Daniel Picard,
- Ian Burns,
- Jason Moffat,
- Kamil Paruch,
- Adam Fleming,
- Kristin Hope,
- John P. Provias,
- Marc Remke,
- Yu Lu,
- Tannishtha Reya,
- Chitra Venugopal,
- Jüri Reimand,
- Robert J. Wechsler-Reya,
- Gene W. Yeo,
- Sheila K. Singh
Affiliations
- Michelle M. Kameda-Smith
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Helen Zhu
- University Health Network
- En-Ching Luo
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Yujin Suk
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Agata Xella
- Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Brian Yee
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Chirayu Chokshi
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Sansi Xing
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Frederick Tan
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Raymond G. Fox
- Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine
- Ashley A. Adile
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- David Bakhshinyan
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Kevin Brown
- Donnelly Centre, Department of Molecular Genetics, University of Toronto
- William D. Gwynne
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Minomi Subapanditha
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Petar Miletic
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Daniel Picard
- Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf
- Ian Burns
- Michael G DeGroote School of Medicine, McMaster University
- Jason Moffat
- Donnelly Centre, Department of Molecular Genetics, University of Toronto
- Kamil Paruch
- Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University
- Adam Fleming
- McMaster University, Departments of Pediatrics, Hematology and Oncology Division
- Kristin Hope
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- John P. Provias
- McMaster University, Departments of Neuropathology
- Marc Remke
- Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf
- Yu Lu
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Tannishtha Reya
- Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine
- Chitra Venugopal
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- Jüri Reimand
- Computational Biology Program, Ontario Institute for Cancer Research
- Robert J. Wechsler-Reya
- Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Gene W. Yeo
- Department of Cellular and Molecular Medicine, University of California at San Diego
- Sheila K. Singh
- Centre for Discovery in Cancer Research (CDCR), McMaster University
- DOI
- https://doi.org/10.1038/s41467-022-35118-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
MYC amplification is an independent prognostic factor for the most aggressive subgroup (Group 3) of pediatric medulloblastoma (G3 MB). Here, the authors highlight the role of the RNA-binding protein, Musashi-1 (MSI1) in G3 MB and identify MSI1-bound targets sharing MYC associated pathways.
