Urinary bladder agenesis and renal hypoplasia potentially related to in utero Zika virus infection

Abstract

This case report describes the clinical findings of a 22-year-old pregnant woman with confirmed Zika virus infection, at 16 weeks of gestation, in Sucre, Colombia. Her ultrasound revealed severe oligohydramnios, intrauterine growth restriction, and a complete absence of the urinary bladder of the fetus. The poor prognosis led to the decision to terminate the pregnancy. Autopsy of the fetus revealed severe bilateral renal hypoplasia. Keywords: Zika, Birth defects, Urinary bladder, Agenesis, Renal hypoplasia, Colombia