Receiving of neuroblasts from bone marrow stromal cells and its clinical application in patients with some diseases of nervous system

Abstract

The possibility of differentiation in vitro of mouse bone marrow stromal cells into progenitor of neuronal cells has been shown with condition of specific medias and some inductors using for cultivation.Reparation on tissue level was more active in mice with experimental ischemia of brain after transformed into neural cells bone marrow stromal cells transplantation.The analysis of clinical efficiency of transformed into neural cells autologous bone marrow stromal cells transplantation has been carried out in patients with stroke, Parkinson’s disease, multiple sclerosis, epilepsy, amyotrophic lateral sclerosis, after-effects of a toxic, traumatic, infective impairment of a nervous system. The results of patients with stroke treatment depended on the disease duration and method of grafting. The efficiency of transformed into neuronal cells autologous bone marrow stromal cells transplantation in patients with Parkinson’s disease depended on the severity degree of the disease, in patients with multiple sclerosis — from degree of disability (scale EDSS). This method is perspective in treatment of after-effects of a toxic, infective impairment of a nervous system, epilepsy. No implant-related adverse events have occurred.