Nature Communications (Mar 2016)
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
- Caroline P. Le,
- Cameron J. Nowell,
- Corina Kim-Fuchs,
- Edoardo Botteri,
- Jonathan G. Hiller,
- Hilmy Ismail,
- Matthew A. Pimentel,
- Ming G. Chai,
- Tara Karnezis,
- Nicole Rotmensz,
- Giuseppe Renne,
- Sara Gandini,
- Colin W. Pouton,
- Davide Ferrari,
- Andreas Möller,
- Steven A. Stacker,
- Erica K. Sloan
Affiliations
- Caroline P. Le
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Cameron J. Nowell
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Corina Kim-Fuchs
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Edoardo Botteri
- Division of Epidemiology and Biostatistics, European Institute of Oncology
- Jonathan G. Hiller
- Department of Cancer Anaesthesia and Pain Medicine, Peter MacCallum Cancer Centre
- Hilmy Ismail
- Department of Cancer Anaesthesia and Pain Medicine, Peter MacCallum Cancer Centre
- Matthew A. Pimentel
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Ming G. Chai
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Tara Karnezis
- Peter MacCallum Department of Oncology, The University of Melbourne
- Nicole Rotmensz
- Division of Epidemiology and Biostatistics, European Institute of Oncology
- Giuseppe Renne
- Division of Pathology and Laboratory Medicine, European Institute of Oncology
- Sara Gandini
- Division of Epidemiology and Biostatistics, European Institute of Oncology
- Colin W. Pouton
- Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- Davide Ferrari
- Department of Mathematics and Statistics, The University of Melbourne
- Andreas Möller
- Cancer Division, QIMR Berghofer Medical Research Institute
- Steven A. Stacker
- Peter MacCallum Department of Oncology, The University of Melbourne
- Erica K. Sloan
- Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University
- DOI
- https://doi.org/10.1038/ncomms10634
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis.
