Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Chao Zhong
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Lingqing Su
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Manman Qin
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Yanfei Xie
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Dan Shan
Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA
Yaru Cui
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Min Shi
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Min Li
Center for Traditional Chinese Medicine Resources and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Hexiu Quan
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Liang Qiu
Center for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Guoyue Zhong
Center for Traditional Chinese Medicine Resources and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Jun Yu
Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA
Endothelial pro-inflammatory activation is pivotal in cardiac ischemia–reperfusion (I/R) injury pathophysiology. The dried flower bud of Edgeworthia gardneri (Wall.) Meisn. (EG) is a commonly utilized traditional Tibetan medicine. However, its role in regulating endothelium activation and cardiac I/R injury has not been investigated. Herein, we showed that the administration of EG ethanolic extract exhibited a potent therapeutic efficacy in ameliorating cardiac endothelial inflammation (p p p p N-terminal kinase (JNK), extracellular regulated protein kinase (ERK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways to attenuate EC-mediated inflammation (p < 0.05). Collectively, for the first time, this study demonstrated the therapeutic potential of EG ethanolic extract in alleviating I/R-induced inflammation and the resulting cardiac injury through its inhibitory role in regulating endothelium activation.
