Intelligent H2S release coating for regulating vascular remodeling

Bingyang Lu; Xiao Han; Ansha Zhao; Dan Luo; Manfred F. Maitz; Haohao Wang; Ping Yang; Nan Huang

Bioactive Materials (Apr 2021)

Intelligent H2S release coating for regulating vascular remodeling

Bingyang Lu,
Xiao Han,
Ansha Zhao,
Dan Luo,
Manfred F. Maitz,
Haohao Wang,
Ping Yang,
Nan Huang

Affiliations

Bingyang Lu: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Xiao Han: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Ansha Zhao: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; Corresponding author. Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.
Dan Luo: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Manfred F. Maitz: Leibniz-Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Strasse 6, 01069, Dresden, Germany
Haohao Wang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Ping Yang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
Nan Huang: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

Journal volume & issue: Vol. 6, no. 4
pp. 1040 – 1050

Abstract

Read online

Coronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response. Due to insufficient drug release control, drug-eluting stent intervention can lead to delayed endothelialization, advanced thrombosis, and unprecise treatment. In this study, hyaluronic acid and chitosan were used to prepare pH-responsive self-assembling films. The hydrogen sulfide (H2S) releasing aspirin derivative ACS14 was used as drug in the film. The film regulates the release of the drug adjusted to the microenvironment of the lesion, and the drug balances the vascular function by releasing the regulating gas H2S, which comparably to NO promotes the self-healing capacity of blood vessels. Drug releasing profiles of the films at different pH, and other biological effects on blood vessels were evaluated through blood compatibility, cellular, and implantation experiments. This novel method of self-assembled films which H2S in an amount, which is adjusted to the condition of the lesion provides a new concept for the treatment of cardiovascular diseases.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

About the journal

Abstract

Keywords