Nature Communications (Jul 2022)

A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells

  • Haipeng Fu,
  • Tingyu Wang,
  • Xiaohui Kong,
  • Kun Yan,
  • Yang Yang,
  • Jingyi Cao,
  • Yafei Yuan,
  • Nan Wang,
  • Kehkooi Kee,
  • Zhi John Lu,
  • Qiaoran Xi

DOI
https://doi.org/10.1038/s41467-022-31762-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Fu et al. identify the highly conserved, transmembrane micropeptide, NEMEP, as a direct target of Nodal signaling, essential for mesendoderm differentiation. NEMEP interacts with the glucose transporters GLUT1/GLUT3 and promotes glucose uptake.