Nature Communications (Dec 2019)

Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

  • Nikolay Burnaevskiy,
  • Bryan Sands,
  • Soo Yun,
  • Patricia M. Tedesco,
  • Thomas E. Johnson,
  • Matt Kaeberlein,
  • Roger Brent,
  • Alexander Mendenhall

DOI
https://doi.org/10.1038/s41467-019-13664-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.