Strategies for promoting tendon-bone healing: Current status and prospects

Chenhui Yang; Chenhui Yang; Chenhui Yang; Chenhui Yang; Yuanjun Teng; Yuanjun Teng; Yuanjun Teng; Bin Geng; Bin Geng; Bin Geng; Hefang Xiao; Hefang Xiao; Hefang Xiao; Changshun Chen; Changshun Chen; Changshun Chen; Rongjin Chen; Rongjin Chen; Rongjin Chen; Fei Yang; Fei Yang; Fei Yang; Yayi Xia; Yayi Xia; Yayi Xia

doi:10.3389/fbioe.2023.1118468

Frontiers in Bioengineering and Biotechnology (Jan 2023)

Strategies for promoting tendon-bone healing: Current status and prospects

Chenhui Yang,
Chenhui Yang,
Chenhui Yang,
Chenhui Yang,
Yuanjun Teng,
Yuanjun Teng,
Yuanjun Teng,
Bin Geng,
Bin Geng,
Bin Geng,
Hefang Xiao,
Hefang Xiao,
Hefang Xiao,
Changshun Chen,
Changshun Chen,
Changshun Chen,
Rongjin Chen,
Rongjin Chen,
Rongjin Chen,
Fei Yang,
Fei Yang,
Fei Yang,
Yayi Xia,
Yayi Xia,
Yayi Xia

Affiliations

Chenhui Yang: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Chenhui Yang: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Chenhui Yang: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Chenhui Yang: Department of Orthopedic, Tianshui Hand and Foot Surgery Hospital, Tianshui, China
Yuanjun Teng: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Yuanjun Teng: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Yuanjun Teng: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Bin Geng: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Bin Geng: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Bin Geng: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Hefang Xiao: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Hefang Xiao: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Hefang Xiao: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Changshun Chen: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Changshun Chen: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Changshun Chen: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Rongjin Chen: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Rongjin Chen: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Rongjin Chen: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Fei Yang: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Fei Yang: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Fei Yang: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China
Yayi Xia: Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China
Yayi Xia: Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Yayi Xia: The Second School of Clinical Medical, Lanzhou University, Lanzhou, China

DOI: https://doi.org/10.3389/fbioe.2023.1118468
Journal volume & issue: Vol. 11

Abstract

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Tendon-bone insertion (TBI) injuries are common, primarily involving the rotator cuff (RC) and anterior cruciate ligament (ACL). At present, repair surgery and reconstructive surgery are the main treatments, and the main factor determining the curative effect of surgery is postoperative tendon-bone healing, which requires the stable combination of the transplanted tendon and the bone tunnel to ensure the stability of the joint. Fibrocartilage and bone formation are the main physiological processes in the bone marrow tract. Therefore, therapeutic measures conducive to these processes are likely to be applied clinically to promote tendon-bone healing. In recent years, biomaterials and compounds, stem cells, cell factors, platelet-rich plasma, exosomes, physical therapy, and other technologies have been widely used in the study of promoting tendon-bone healing. This review provides a comprehensive summary of strategies used to promote tendon-bone healing and analyses relevant preclinical and clinical studies. The potential application value of these strategies in promoting tendon-bone healing was also discussed.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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