Nature Communications (Jun 2022)
Defining TCRγδ lymphoproliferative disorders by combined immunophenotypic and molecular evaluation
- Antonella Teramo,
- Andrea Binatti,
- Elena Ciabatti,
- Gianluca Schiavoni,
- Giulia Tarrini,
- Gregorio Barilà,
- Giulia Calabretto,
- Cristina Vicenzetto,
- Vanessa Rebecca Gasparini,
- Monica Facco,
- Iacopo Petrini,
- Roberto Grossi,
- Nadia Pisanti,
- Stefania Bortoluzzi,
- Brunangelo Falini,
- Enrico Tiacci,
- Sara Galimberti,
- Gianpietro Semenzato,
- Renato Zambello
Affiliations
- Antonella Teramo
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Andrea Binatti
- Department of Molecular Medicine, University of Padova
- Elena Ciabatti
- Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa
- Gianluca Schiavoni
- Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia
- Giulia Tarrini
- Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa
- Gregorio Barilà
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Giulia Calabretto
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Cristina Vicenzetto
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Vanessa Rebecca Gasparini
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Monica Facco
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Iacopo Petrini
- Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa
- Roberto Grossi
- Department of Computer Science, University of Pisa
- Nadia Pisanti
- Department of Computer Science, University of Pisa
- Stefania Bortoluzzi
- Department of Molecular Medicine, University of Padova
- Brunangelo Falini
- Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia
- Enrico Tiacci
- Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia
- Sara Galimberti
- Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa
- Gianpietro Semenzato
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Renato Zambello
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31015-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Tγδ large granular lymphocyte leukemia (Tγδ LGLL) is a rare lymphoproliferative neoplasm characterized by the expansion of T large granular lymphocytes expressing γδ TCR. Here, based on deep sequencing analysis of the clonotype repertoire, the authors show that leukemic Tγδ cells are characterized by recurrent public clonotypes that are diversified between symptomatic and asymptomatic patients.
