Open Medicine
(Feb 2015)
Effects of hypothermia on skeletal ischemia
reperfusion injury in rats
Ekinci Şafak,
Kaldırım Ümit,
Akyıldız Faruk,
Bilgiç Serkan,
Koca Kenan,
Poyrazoğlu Yavuz,
Uysal Ozgür Selim,
Turğut Hasan,
Türkkan Selim,
Erşen Ömer,
Topal Turgut,
Ozkan Huseyin
Affiliations
Ekinci Şafak
Department of Orthopaedics and Traumatology, Malatya Military Hospital, Malatya, Turkey
Kaldırım Ümit
Department of Emergency Medicine, Gulhane Military Medical Academy, Ankara, Turkey
Akyıldız Faruk
Department of Orthopaedics and Traumatology, Malatya Military Hospital, Malatya, Turkey
Bilgiç Serkan
Department of Orthopaedics and Traumatology, Haydarpaşa Military Hospital, İstanbul, Turkey
Koca Kenan
Department of Orthopaedics and Traumatology, Gulhane Military Medical Academy, Ankara, Turkey
Poyrazoğlu Yavuz
Department of General Surgery, Mevki Military Hospital, Ankara, Turkey
Uysal Ozgür Selim
Department of Emergency Medicine, Gulhane Military Medical Academy, Ankara, Turkey
Turğut Hasan
Department of Orthopaedics and Traumatology, Bursa Military Hospital, Bursa, Turkey
Türkkan Selim
Department of Orthopaedics and Traumatology, Gulhane Military Medical Academy, Ankara, Turkey
Erşen Ömer
Department of Orthopaedics and Traumatology, Erzurum Military Hospital, Erzurum, Turkey
Topal Turgut
Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
Ozkan Huseyin
Department of Orthopaedics and Traumatology, Gulhane Military Medical Academy, Ankara, Turkey
DOI
https://doi.org/10.1515/med-2015-0031
Journal volume & issue
Vol. 10,
no. 1
Abstract
Read online
Objective: The aim of this study was to investigate the effect of hypothermia (H) on skeletal ischemia-reperfusion (IR) injury in rats by measuring malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), nitric oxide (NO), and interleukin-1 beta (IL-1β) in muscle, and measureing immunohistochemical- inducible nitric oxide synthase (iNOS) staining of skeletal muscle.
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