Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

Marjory Koller; Si-Qi Qiu; Matthijs D. Linssen; Liesbeth Jansen; Wendy Kelder; Jakob de Vries; Inge Kruithof; Guo-Jun Zhang; Dominic J. Robinson; Wouter B. Nagengast; Annelies Jorritsma-Smit; Bert van der Vegt; Gooitzen M. van Dam

doi:10.1038/s41467-018-05727-y

Nature Communications (Sep 2018)

Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

Marjory Koller,
Si-Qi Qiu,
Matthijs D. Linssen,
Liesbeth Jansen,
Wendy Kelder,
Jakob de Vries,
Inge Kruithof,
Guo-Jun Zhang,
Dominic J. Robinson,
Wouter B. Nagengast,
Annelies Jorritsma-Smit,
Bert van der Vegt,
Gooitzen M. van Dam

Affiliations

Marjory Koller: Department of Surgery, University Medical Center Groningen, University of Groningen
Si-Qi Qiu: Department of Surgery, University Medical Center Groningen, University of Groningen
Matthijs D. Linssen: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen
Liesbeth Jansen: Department of Surgery, University Medical Center Groningen, University of Groningen
Wendy Kelder: Department of Surgery, Martini Hospital
Jakob de Vries: Department of Surgery, University Medical Center Groningen, University of Groningen
Inge Kruithof: Department of Pathology, Martini Hospital
Guo-Jun Zhang: Changjiang Scholar′s Laboratory of Shantou University Medical College
Dominic J. Robinson: Erasmus Medical Center Rotterdam
Wouter B. Nagengast: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen
Annelies Jorritsma-Smit: Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen
Bert van der Vegt: Department of Pathology, University Medical Center Groningen, University of Groningen
Gooitzen M. van Dam: Department of Surgery, University Medical Center Groningen, University of Groningen

DOI: https://doi.org/10.1038/s41467-018-05727-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Fluorescent tracers are being tested in clinical trials to improve detection of tumor margins, but procedures are not standardised. Here, the authors develop an analytical framework that is compatible with the workflow in the operating theatre, and show that it leads to an 88% increase in intraoperative detection of tumor margins in patients with breast cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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