γδ T cells in 3D culture: The potential use in the therapeutics development

Abstract

Abstract Gamma‐delta (γδ) T cells have a promising future in various therapies due to their anti‐cancer and anti‐infectious function. As the unique T cell subset plays a vital role in the connection between innate and adaptive immunity, we discussed the potential application of γδ T cell‐based therapy combined with other anti‐tumour treatments. For comprehensive investigation, a three‐dimensional (3D) cell culture system can be applied to evaluate the therapeutic efficacy of γδ T cells. Hence, we also summarized and discussed the potential use of the 3D cell culture system for therapeutic developments in γδ T cells.

Keywords

• 3D cell culture
• CAR‐T
• immune checkpoint blockade
• SARS‐CoV‐2
• γδ T cell