Synthesis and Antibacterial Studies of new mixed ligand transition metal complexes of thioester (1, 3, 4-Oxadiazole) derivative (phozbt) and dppe Ligands.

Abstract

Complexes of transition palladium(II) and platinum(II) metals that possessing two kinds of ligands: S-5-phenyl -1, 3, 4-oxadiazole-2-yl benzothioate (phozbt) and tertiary diphosphine (dppe), were synthesized. The thioester (phozbt) ligand was synthesized by reaction between 2-mercapto-5-phenyl-1,3,4-oxadiazole (PhozSH) with benzoyl chloride and using sodium hydroxide. The synthesized ligand and complexes were described by C, H, N, S analysis, infrared spectra, molar conductivity, UV-visible and magnetic susceptibility measurements. The (dppe) act as bidentate chelate that linked to the metals on both P-donor atoms. According to the spectral analysis of the complexes, a square planer structure were suggested for both metal complexes. The ligand and complexes were studied for antibacterial activity by using agar diffusion method. This study showed positive inhibition zone results, for both ligand and complexes with S. aureus and P. aeruginosa bacteria.

Keywords

• Pd(II), Pt(II), Oxadiazole derivatives, Dppe, Antibacterial activity