Nature Communications (Jun 2016)

Unravelling the structural plasticity of stretched DNA under torsional constraint

  • Graeme A. King,
  • Erwin J. G. Peterman,
  • Gijs J. L. Wuite

DOI
https://doi.org/10.1038/ncomms11810
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

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Cellular DNA is often torsionally constrained, but the topologies that such DNA can adopt under tensile strain have remained largely untested. Here, the authors use single-molecule optical tweezers to illustrate the structural plasticity of torsionally constrained DNA under mechanical force.