São Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil
Isys F. Mello
São Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil
Luciano S. Ricco
Science Institute, University of Iceland, Dunhagi-3, IS-107, Reykjavik, Iceland
Marcos F. Minicucci
Department of Internal Medicine, Botucatu Medical School, UNESP – Univ Estadual Paulista, Botucatu, Brazil
Aniekan Magnus Ukpong
Theoretical and Computational Condensed Matter and Materials Physics Group, School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa; National Institute for Theoretical and Computational Sciences (NITheCS), KwaZulu-Natal, South Africa
Antonio C. Seridonio
São Paulo State University (Unesp), Department of Physics and Chemistry, Ilha Solteira - SP, Brazil
Roberto E. Lagos-Monaco
São Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil
Mariano de Souza
São Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil; Corresponding author.
Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.
