IL-13 May Could Enhance the Proliferation and Affect the Differentiation of Nasal Epithelium Basal Cells Through the mTOR/p70S6K1 Pathway in Chronic Rhinosinusitis With Nasal Polyps

Ping Li; Tao Li; Jinfeng Luo; Peng Yu; Tao Jiang; Xiangmin Zhou; Liang Yu; Aiping Chen; Yuzhu Wan; Li Shi

doi:10.1155/mi/8108993

Mediators of Inflammation (Jan 2025)

IL-13 May Could Enhance the Proliferation and Affect the Differentiation of Nasal Epithelium Basal Cells Through the mTOR/p70S6K1 Pathway in Chronic Rhinosinusitis With Nasal Polyps

Ping Li,
Tao Li,
Jinfeng Luo,
Peng Yu,
Tao Jiang,
Xiangmin Zhou,
Liang Yu,
Aiping Chen,
Yuzhu Wan,
Li Shi

Affiliations

Ping Li: Department of Otolaryngology-Head and Neck Surgery
Tao Li: Department of Otolaryngology-Head and Neck Surgery
Jinfeng Luo: Department of Otolaryngology-Head and Neck Surgery
Peng Yu: Department of Otolaryngology-Head and Neck Surgery
Tao Jiang: Department of Otolaryngology-Head and Neck Surgery
Xiangmin Zhou: Department of Otolaryngology-Head and Neck Surgery
Liang Yu: Department of Otolaryngology-Head and Neck Surgery
Aiping Chen: Department of Otolaryngology-Head and Neck Surgery
Yuzhu Wan: Department of Otolaryngology-Head and Neck Surgery
Li Shi: Department of Otolaryngology-Head and Neck Surgery

DOI: https://doi.org/10.1155/mi/8108993
Journal volume & issue: Vol. 2025

Abstract

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Conclusion: IL-13 may affect the proliferation and differentiation of nasal epithelial progenitor/stem cells through the mTOR/p70S6K1 pathway, which may affect the development of nasal polyps.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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