Molecules (Mar 2013)

A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli

  • Ping-Jyun Sung,
  • Zhi-Hong Wen,
  • Chan-Shing Lin,
  • Yung-Husan Chen,
  • Jyh-Horng Sheu,
  • Yu-Chia Chang,
  • Yu-Hsin Chen,
  • Yin-Di Su,
  • Jui-Hsin Su,
  • Chang-Feng Dai,
  • Mei-Chin Lu,
  • Ching-Hsiao Cheng,
  • Wei-Hsuan Yen,
  • Wu-Fu Chen

DOI
https://doi.org/10.3390/molecules18032895
Journal volume & issue
Vol. 18, no. 3
pp. 2895 – 2903

Abstract

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A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1–3 towards various tumor cells is reported.

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