Nature Communications (Mar 2016)

Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography

  • Lei Zhang,
  • Dongsheng Lei,
  • Jessica M. Smith,
  • Meng Zhang,
  • Huimin Tong,
  • Xing Zhang,
  • Zhuoyang Lu,
  • Jiankang Liu,
  • A. Paul Alivisatos,
  • Gang Ren

DOI
https://doi.org/10.1038/ncomms11083
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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The control of DNA-mediated assembly depends on a precise understanding of the three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Here, the authors use cryo-electron microscopy and negative-staining techniques to investigate the morphology of DNA-nanogold conjugates.