Nature Communications (Jul 2020)
A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
- Ningfei Li,
- Juan Carlos Baldermann,
- Astrid Kibleur,
- Svenja Treu,
- Harith Akram,
- Gavin J. B. Elias,
- Alexandre Boutet,
- Andres M. Lozano,
- Bassam Al-Fatly,
- Bryan Strange,
- Juan A. Barcia,
- Ludvic Zrinzo,
- Eileen Joyce,
- Stephan Chabardes,
- Veerle Visser-Vandewalle,
- Mircea Polosan,
- Jens Kuhn,
- Andrea A. Kühn,
- Andreas Horn
Affiliations
- Ningfei Li
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology
- Juan Carlos Baldermann
- Department of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical Faculty
- Astrid Kibleur
- Univ. Grenoble Alpes
- Svenja Treu
- Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid
- Harith Akram
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology
- Gavin J. B. Elias
- University Health Network
- Alexandre Boutet
- University Health Network
- Andres M. Lozano
- University Health Network
- Bassam Al-Fatly
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology
- Bryan Strange
- Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid
- Juan A. Barcia
- Hospital Clínico San Carlos, Neurosurgery Department, Universidad Complutense de Madrid
- Ludvic Zrinzo
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology
- Eileen Joyce
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology
- Stephan Chabardes
- Univ. Grenoble Alpes
- Veerle Visser-Vandewalle
- Department of Stereotactic and Functional Neurosurgery, University of Cologne
- Mircea Polosan
- Univ. Grenoble Alpes
- Jens Kuhn
- Department of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical Faculty
- Andrea A. Kühn
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology
- Andreas Horn
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for Neurology
- DOI
- https://doi.org/10.1038/s41467-020-16734-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.
