Nature Communications (May 2022)
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α
- Xiaotong Diao,
- Fei Ye,
- Meina Zhang,
- Xintong Ren,
- Xiaoxu Tian,
- Jingping Lu,
- Xiangnan Sun,
- Zeng Hou,
- Xiaoyu Chen,
- Fengwei Li,
- Jingjing Zhuang,
- Hong Ding,
- Chao Peng,
- Fraydoon Rastinejad,
- Cheng Luo,
- Dalei Wu
Affiliations
- Xiaotong Diao
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Fei Ye
- School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Meina Zhang
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Xintong Ren
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Xiaoxu Tian
- National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science
- Jingping Lu
- Target Discovery Institute, NDM Research Building, University of Oxford
- Xiangnan Sun
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Zeng Hou
- School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
- Xiaoyu Chen
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Fengwei Li
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Jingjing Zhuang
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- Hong Ding
- Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Chao Peng
- National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science
- Fraydoon Rastinejad
- Target Discovery Institute, NDM Research Building, University of Oxford
- Cheng Luo
- School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Dalei Wu
- Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University
- DOI
- https://doi.org/10.1038/s41467-022-30338-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Whether hypoxia-inducible factors (HIFs) can be directly regulated by endogenous small molecules is a long-standing question. Here authors identified the metabolite oleoylethanolamide as a HIF-3α ligand and further revealed its mechanism of action.
